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1

Making Sense of the Cytokine Storm: A Conceptual Framework for Understanding, Diagnosing, and Treating Hemophagocytic Syndromes

Scott W. Canna, Edward M. Behrens

Journal:

Pediatric Clinics of North America

Year:

2012

Language:

english

File:

PDF, 304 KB

english, 2012

2

Introduction: Autoinflammatory Syndromes Special Issue—hidden mysteries in the corners of autoinflammation

Canna, Scott W, Goldbach-Mansky, Raphaela

Journal:

International Immunology

Year:

2018

Language:

english

File:

PDF, 43 KB

english, 2018

3

On the alert for cytokine storm: Immunopathology in COVID-19

Henderson, Lauren A., Canna, Scott W., Schulert, Grant S., Volpi, Stefano, Lee, Pui Y., Kernan, Kate F., Caricchio, Roberto, Mahmud, Shawn, Hazen, Melissa M., Halyabar, Olha, Hoyt, Kacie J., Han, Jose

Journal:

Arthritis & Rheumatology

Year:

2020

File:

PDF, 5.79 MB

2020

4

Pediatric hemophagocytic lymphohistiocytosis

Canna, Scott W., Marsh, Rebecca A.

Journal:

Year:

2020

File:

PDF, 1007 KB

2020

5

Acute hepatitis in three patients with systemic juvenile idiopathic arthritis taking interleukin-1 receptor antagonist

Scott Canna, Jennifer Frankovich, Gloria Higgins, Michael R Narkewicz, S Russell Nash, J Roger Hollister, Jennifer B Soep, Leonard L Dragone

Journal:

Pediatric Rheumatology

Year:

2009

Language:

english

File:

PDF, 935 KB

english, 2009

6

Arthropathy of neonatal onset multisystem inflammatory disease (NOMID/CINCA)

Suvimol Chirathivat Hill, Madjimbaye Namde, Andrew Dwyer, Andrew Poznanski, Scott Canna, Raphaela Goldbach-Mansky

Journal:

Pediatric Radiology

Year:

2007

Language:

english

File:

PDF, 454 KB

english, 2007

7

IL-10 is a critical negative regulator of macrophage activation syndrome

Scott Canna,Katharine Slade,Michele Paessler,Portia Kreiger…

Journal:

Pediatric Rheumatology

Year:

2012

Language:

english

File:

PDF, 84 KB

english, 2012

8

PR_001: Functional Outcomes of 1 Year of Treatment of Neonatal Onset Multisystem Inflammatory Disease With Anakinra

Scott M. Paul, Madjimbaye Namde, Hanna Hildenbrand, Minal S. Jain, Michaele Smith, Scott Canna

Journal:

Archives of Physical Medicine and Rehabilitation

Year:

2006

Language:

english

File:

PDF, 55 KB

english, 2006

9

A 17 year old with isolated proximal tibiofibular joint arthritis

Scott W Canna, Nancy A Chauvin, Jon M Burnham

Journal:

Pediatric Rheumatology

Year:

2013

Language:

english

File:

PDF, 302 KB

english, 2013

10

Neonatal-Onset Multisystem Inflammatory Disease Responsive to Interleukin-1β Inhibition

Goldbach-Mansky, Raphaela, Dailey, Natalie J., Canna, Scott W., Gelabert, Ana, Jones, Janet, Rubin, Benjamin I., Kim, H. Jeffrey, Brewer, Carmen, Zalewski, Christopher, Wiggs, Edythe, Hill, Suvimol, T

Journal:

Boston Medical and Surgical Journal

Year:

2006

Language:

english

File:

PDF, 315 KB

english, 2006

11

An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome

Canna, Scott W, de Jesus, Adriana A, Gouni, Sushanth, Brooks, Stephen R, Marrero, Bernadette, Liu, Yin, DiMattia, Michael A, Zaal, Kristien J M, Sanchez, Gina A Montealegre, Kim, Hanna, Chapelle, Dawn

Journal:

Nature Genetics

Year:

2014

Language:

english

File:

PDF, 1.05 MB

english, 2014

12

Interferon-γ Mediates Anemia but Is Dispensable for Fulminant Toll-like Receptor 9-Induced Macrophage Activation Syndrome and Hemophagocytosis in Mice

Canna, Scott W., Wrobel, Julia, Chu, Niansheng, Kreiger, Portia A., Paessler, Michele, Behrens, Edward M.

Journal:

Arthritis & Rheumatism

Year:

2013

Language:

english

File:

PDF, 765 KB

english, 2013

13

Editorial: Interferon-γ: Friend or Foe in Systemic Juvenile Idiopathic Arthritis and Adult-Onset Still's Disease?

Canna, Scott W.

Journal:

Arthritis & Rheumatology

Year:

2014

Language:

english

File:

PDF, 93 KB

english, 2014

14

Brief Report: Alternative Activation of Laser-Captured Murine Hemophagocytes

Canna, Scott W., Costa-Reis, Patrícia, Bernal, William E., Chu, Niansheng, Sullivan, Kathleen E., Paessler, Michele E., Behrens, Edward M.

Journal:

Arthritis & Rheumatology

Year:

2014

Language:

english

File:

PDF, 117 KB

english, 2014

15

Molecular Mechanisms in Genetically Defined Autoinflammatory Diseases: Disorders of Amplified Danger Signaling*

de Jesus, Adriana Almeida, Canna, Scott W., Liu, Yin, Goldbach-Mansky, Raphaela

Journal:

Annual Review of Immunology

Year:

2015

Language:

english

File:

PDF, 4.12 MB

english, 2015

16

Not all hemophagocytes are created equally

Canna, Scott W., Behrens, Edward M.

Journal:

Current Opinion in Rheumatology

Year:

2012

Language:

english

File:

PDF, 225 KB

english, 2012

17

New monogenic autoinflammatory diseases—a clinical overview

Canna, Scott W., Goldbach-Mansky, Raphaela

Journal:

Seminars in Immunopathology

Year:

2015

Language:

english

File:

PDF, 738 KB

english, 2015

18

A157: Macrophage Activation Syndrome-like Illness Due to an Activating Mutation in NLRC4

Canna, Scott, de Jesus, Adriana Almeida, Deng, Zuoming, Gouni, Sushanth, Marrero, Bernadette, Brooks, Stephen, Dimattia, Michael, Liu, Yin, Huang, Yan, Plass, Nicole, Chapelle, Dawn C., Montealegre, G

Journal:

Arthritis & Rheumatology

Year:

2014

Language:

english

File:

PDF, 40 KB

english, 2014

19

Editorial: 21st Century Storm Chasers: Defining Macrophage Activation Syndrome

Canna, Scott W., Nigrovic, Peter A.

Journal:

Arthritis & Rheumatology

Year:

2016

Language:

english

File:

PDF, 73 KB

english, 2016

20

Life-threatening NLRC4-associated hyperinflammation successfully treated with Interleukin-18 inhibition

Canna, Scott W., Girard, Charlotte, Malle, Louise, de Jesus, Adriana, Romberg, Neil, Kelsen, Judith, Surrey, Lea F., Russo, Pierre, Sleight, Andrew, Schiffrin, Eduardo, Gabay, Cem, Goldbach-Mansky, Ra

Journal:

Journal of Allergy and Clinical Immunology

Year:

2016

Language:

english

File:

PDF, 21.95 MB

english, 2016

21

IL-10 distinguishes a unique population of activated, effector-like CD8 + T cells in murine acute liver inflammation

Rood, Julia E., Canna, Scott W., Weaver, Lehn K., Tobias, John W., Behrens, Edward M.

Journal:

Journal of Leukocyte Biology

Year:

2017

Language:

english

File:

PDF, 1.36 MB

english, 2017

22

No shortcuts

Tsoukas, Paul, Canna, Scott W.

Journal:

Current Opinion in Rheumatology

Year:

2017

Language:

english

File:

PDF, 522 KB

english, 2017

23

Reply

Canna, Scott W., Girard, Charlotte, Malle, Louise, de Jesus, Adriana, Romberg, Neil, Kelsen, Judith, Surrey, Lea F., Russo, Pierre, Sleight, Andrew, Schiffrin, Eduardo, Gabay, Cem, Goldbach-Mansky, Ra

Journal:

Journal of Allergy and Clinical Immunology

Year:

2017

Language:

english

File:

PDF, 81 KB

english, 2017

24

A novel Pyrin-Associated Autoinflammation with Neutrophilic Dermatosis mutation further defines 14-3-3 binding of pyrin and distinction to Familial Mediterranean Fever

Moghaddas, Fiona, Llamas, Rafael, De Nardo, Dominic, Martinez-Banaclocha, Helios, Martinez-Garcia, Juan J, Mesa-del-Castillo, Pablo, Baker, Paul J, Gargallo, Vanessa, Mensa-Vilaro, Anna, Canna, Scott,

Journal:

Annals of the Rheumatic Diseases

Year:

2017

Language:

english

File:

PDF, 10.10 MB

english, 2017

25

NLRC4 inflammasomopathies

Romberg, Neil, Vogel, Tiphanie P., Canna, Scott W.

Journal:

Current Opinion in Allergy and Clinical Immunology

Year:

2017

Language:

english

File:

PDF, 460 KB

english, 2017

26

The NLRC4 Inflammasome

Duncan, Joseph A., Canna, Scott W.

Journal:

Immunological Reviews

Year:

2018

Language:

english

File:

PDF, 477 KB

english, 2018

27

A20 haploinsufficiency (HA20): clinical phenotypes and disease course of patients with a newly recognised NF-kB-mediated autoinflammatory disease

Aeschlimann, Florence A, Batu, Ezgi D, Canna, Scott W, Go, Ellen, Gül, Ahmet, Hoffmann, Patrycja, Leavis, Helen L, Ozen, Seza, Schwartz, Daniella M, Stone, Deborah L, van Royen-Kerkof, Annet, Kastner,

Journal:

Annals of the Rheumatic Diseases

Year:

2018

Language:

english

File:

PDF, 727 KB

english, 2018

28

Convergent pathways of the hyperferritinemic syndromes

Schulert, Grant S, Canna, Scott W

Journal:

International Immunology

Year:

2018

Language:

english

File:

PDF, 791 KB

english, 2018

29

Chronic, Systemic Interleukin-18 Does Not Promote Macular Degeneration or Choroidal Neovascularization

Canna, Scott W., Shi, Guangpu, Gery, Igal, Sen, H. Nida

Journal:

Investigative Opthalmology & Visual Science

Year:

2017

Language:

english

File:

PDF, 248 KB

english, 2017

30

IL-18 as a biomarker linking systemic juvenile idiopathic arthritis and macrophage activation syndrome

Yasin, Shima, Fall, Ndate, Brown, Rachel A, Henderlight, Maggie, Canna, Scott W, Girard-Guyonvarc’h, Charlotte, Gabay, Cem, Grom, Alexei A, Schulert, Grant S

Journal:

Year:

2019

Language:

english

File:

PDF, 484 KB

english, 2019

31

A novel de novo NLRC4 mutation reinforces the likely pathogenicity of specific LRR domain mutation

Chear, Chai Teng, Nallusamy, Revathy, Canna, Scott W., Chan, Kwai Cheng, Baharin, Mohd Farid, Hishamshah, Munirah, Ghani, Hamidah, Ripen, Adiratna Mat, Mohamad, Saharuddin Bin

Journal:

Clinical Immunology

Year:

2020

File:

PDF, 940 KB

2020

32

1690

Aldewereld, Zachary, Carcillo, Joseph, Parker, Robert, Canna, Scott, Clermont, Gilles

Journal:

Critical Care Medicine

Year:

2020

File:

PDF, 60 KB

2020

33

Should COVID-19 take advice from rheumatologists?

Kernan, Kate F, Canna, Scott W

Journal:

The Lancet Rheumatology

Year:

2020

File:

PDF, 79 KB

2020

34

Interleukin-18 and cytotoxic impairment are independent and synergistic causes of murine virus-induced hyperinflammation

Tsoukas, Paul, Rapp, Emily, Van Der Kraak, Lauren, Weiss, Eric S, Dang, Vinh, Schneider, Corinne, Klein, Edwin, Picarsic, Jennifer, Salcedo, Rosalba, Stewart, Charles Andrew, Canna, Scott

Journal:

Year:

2020

File:

PDF, 4.25 MB

2020

35

Proceedings from the 2nd Next Gen Therapies for Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome symposium held on October 3-4, 2019

Canna, Scott W., Schulert, Grant S., de Jesus, Adriana, Pickering, Alex, Brunner, Hermine, Gadina, Massimo, Levine, Stewart, Goldbach-Mansky, Raphaela, Boutelle, Jonathan, Sinha, Rashmi, DeBenedetti,

Journal:

Pediatric Rheumatology

Year:

2020

File:

PDF, 883 KB

2020

36

American College of Rheumatology Clinical Guidance for Pediatric Patients with Multisystem Inflammatory Syndrome in Children (MISâC) Associated with SARSâCoVâ2 and Hyperinflammation in COVIDâ19. Version 1

Henderson, Lauren A., Canna, Scott W., Friedman, Kevin G., Gorelik, Mark, Lapidus, Sivia K., Bassiri, Hamid, Behrens, Edward M., Ferris, Anne, Kernan, Kate F., Schulert, Grant S., Seo, Philip, F. Son,

Journal:

Arthritis & Rheumatology

Year:

2020

File:

PDF, 17.96 MB

2020

37

Highways to hell: Mechanism-based management of cytokine storm syndromes

Canna, Scott W., Cron, Randy Q.

Journal:

Journal of Allergy and Clinical Immunology

Year:

2020

File:

PDF, 274 KB

2020